Skip to main content

Cheap bus tickets from Knoxville, TN to Columbia, SC

Comfort on board

Our buses are equipped with large and comfortable seats, a toilet, Wi-Fi and power outlets.
Our onboard service

Health and Safety

Keep yourself and others safe while traveling with us.
Learn more

Satisfied Customers

We've transported 100+ million happy customers worldwide. US customers give us an amazing 4.5 stars.
Read customer reviews

The Green Choice

FlixBus is one of the most eco-friendly ways to travel. Learn more about our sustainability initiatives and carbon offset programs.
Offset emissions for your trips

On this page

Bus stations and stops in Knoxville, TN

Please note: your ticket will contain the most up-to-date address information.

Discover all destinations

Choose from over 80 travel destinations in 11 states and growing!

Frequently asked questions

With FlixBus, you can conveniently reach 24 destinations from Columbia, including Atlanta, Charlotte, North Charleston.
Yes, night trip options are available from Knoxville to Columbia. Check out the route's schedule and choose the best option to suit your plans!
The fastest bus from Knoxville to Columbia takes 11 hours 50 minutes.
The bus journey from Knoxville to Columbia is 451 miles. FlixBus can get you there in 11 hours 50 minutes.
When purchasing your bus ticket from Knoxville to Columbia, you can choose your preferred payment method from card, Paypal, Google Pay, and more.
Our Real-Time Bus Tracker allows you to track your bus location. Just select the relevant bus stop and check the time of arrival. This way, you can find out where your bus is and check for delays on the route.

Find the cheapest buses from Knoxville to Columbia

Getting from Knoxville to Columbia is cheap and easy when you travel with FlixBus. The two cities are 451 miles apart and traveling between the two takes as fast as 11 hours 50 minutes.
FlixBus tickets are always good value, but you can save even more money by booking online in advance. Book on the website or our FlixBus App in minutes, then simply use your phone as your ticket to board the bus.

For a quick, easy and environmentally-conscious choice, travel with FlixBus.
We have a large network of destinations, so you can trust us to take you from your desired departure city to your destination in comfort and style - all for great value.

Taking the bus from Knoxville

Traveling from Knoxville and not familiar with it? Here's everything you need to know.
Knoxville is a transport hub with 1 bus station(s); the 23 connections departing from Knoxville every day take travelers both within the state and further afield.

Arriving in Columbia

Traveling to Columbia for the first time? Here's what you need to know:
Columbia is very well connected to other destinations on the FlixBus network, with 24 connections arriving in one of the 1 bus station(s) of the city, giving you easy access to all corners of the country.

What to expect onboard the FlixBus bus from Knoxville to Columbia

Getting from Knoxville to Columbia aboard a FlixBus bus means traveling in comfort and style, with all the services you need to keep you occupied. Most of our buses include free Wi-Fi onboard, an entertainment system, toilets and power outlets.
You can bring one carry-on and one check-in piece of luggage per passenger, so even if you're taking a long trip, you don't need to worry about traveling light.
All ticket holders are guaranteed a seat on our buses but if you want to reserve a seat, you can do so at the time of booking. Choose from a classic seat, table seat, panorama seat or extra seat.
Just book online or on our FlixBus App when purchasing your ticket using any of our available payment methods.

Onboard services are subject to availability